Emmanuel Ledesma: Chemistry, Week Seven
I cannot believe this was my last week in the lab and I am sad to see it all come to an end. This week we primarily focused on making our posters to present on our last day. We were to make three posters per group and each poster included the analysis method used to […]
Emmanuel Ledesma: Chemistry, Week Six
This week in the lab we completed our task of ranking the 12 ligands in order from the lowest IC50 to the highest. We were able to accomplish this by using three analysis methods we chose. The methods included: free energy, secondary structure, and hydrogen bond analysis. After analyzing our data from the free energy […]
Emmanuel Ledesma: Chemistry, Week Five
This week in lab, the fun had began as we started to do research for the lab. The first half of my internship, I had been learning the fundamentals and different analysis methods used to analyze proteins. Our task now was to find new methods to predict the rank order of the ligands by their […]
Emmanuel Ledesma: Chemistry, Week Four
This week in the lab we continued working with two more analyses to run on our Hsp90 systems. These will be the last analyses that our mentors will teach us. The main purpose of all of these analyses we have learned are to see if there’s any correlation between each system and their IC50 value. […]
Emmanuel Ledesma: Chemistry, Week Three
My third week in the lab consisted of working with three new analysis. The first is called System Energy Analysis. System Energy Analysis focuses on analyzing the correlation of system energy with measured IC50 values. What this basically does is it takes the average energy for each ligand, there’s six in total, and compares it […]
Emmanuel Ledesma: Chemistry, Week Two
The second week of my internship was just as exciting as my first. This week we primarily focused on analyses that we have to run in Molecular Dynamics (MD) simulations. Molecular Dynamics simulations are used to see how structures change over time compared to the starting point. The week started off by learning about the […]
Emmanuel Ledesma: Chemistry, Week One
My name is Emmanuel Ledesma and I am one of the interns from Olathe High School. Myself and Tyler, another Pinhead Intern, are working with the Amaro Lab at the University of California, San Diego(UCSD). My journey started on Sunday, June 24, as I flew into San Diego. I got to see part of San […]